Parikh was born on 14 February 1929 at Vadnagar (now in Mehsana district, Gujarat, India) in a Vaishnava family. He became orphan when he was one and half years old. He was raised by his uncle and aunt, first in Bombay and then in Vadnagar. He studied Ayurveda at Jamnagar Ayurveda College and served as a doctor in government hospital for brief period. He studied in Bombay and became an eye surgeon. With Dr. Dwarkadas Joshi, he founded the Nagrik Mandal Hospital in Vadnagar where he served for rest of his life. He started a TB Hospital in memory of his sister.
He was a member of Gujarat Legislative Assembly from 1967 to 1971, being elected from Kheralu constituency as an independent candidate defeating Shankerji Okhaji Thakore of Indian National Congress. He had won the election with lowest minimum expenses of ₹6,000 (equivalent to ₹320,000 or US$4,000 in 2023). He is considered to be one of former state chief minister and prime minister Narendra Modi's political gurus. He is credited with coining the term 'One vote, One note' meaning give me a vote as well as one rupee donation for election campaign as he had no money to contest the election. He was chief supporter of Dharoi dam and was instrumental in campaign for it. He was defeated in 1972 and 1995 legislative assembly elections.
Vasant-Prabha Hospital in Vadnagar is named after him.
- Raval, Rajendra (2011). The Historical Heritage City -Vadnagar (in Gujarati). Darshita Prakashan. pp. 167–169.
- "Summary of Dr. Vasant Parikh's life". KarunaSetu Trust.
- Ramavat, Shishir (27 January 2016). "જશને બદલે જૂતાં: ચોખ્ખા માણસે હારવા માટે તૈયાર રહેવું!". Sandesh (in Gujarati). Retrieved 14 February 2022.
- "Modi's guru first coined 'one vote, one note' slogan". The Times of India. Rajkot. 21 January 2014. Retrieved 21 January 2014.
- "Statistical Report on General election, 1967 to the Legislative Assembly of Gujarat - Election Commission of India" (PDF). Retrieved 21 January 2014.
- "Karuna Setu Trust".