User:Patricia at GMMB/biohub organization draft
CZ Biohub is a non-profit medical research organization that was created to support the Chan Zuckerberg Initiative's efforts to cure, prevent, or manage all disease by the end of the century. Its aim is to facilitate collaboration between medical, scientific, and engineering researchers from three Bay Area institutions: Stanford University, the University of California, Berkeley (UC Berkeley), and UC San Francisco (UCSF). It also supports research by its own scientists and engineers in its own facilities. It is organized as both a research institute and a network for researchers to find overlap between their own work and scientists and engineers working in different areas or disciplines, to help accelerate research.
The organization's president is Joseph DeRisi, a professor of Biochemistry and Biophysics at UCSF. DeRisi is known for inventing genomic tools to rapidly identify unknown pathogens, work for which he was named a MacArthur Fellow in 2004. Sandra Schmid joined the organization as its chief scientific officer in 2020. As of 2020, the Biohub had 100 employees including operations staff, scientists, data scientists and engineers. Its headquarters are located In San Francisco, adjacent to UCSF's Mission Bay campus.
The Biohub's research is organized around two main projects: a quantitative approach to cell science, including mapping different types of cells; and an infectious disease initiative, which includes research on infection and immunity as well as developing techniques for early detection of emerging pathogens around the world. Additionally, the organization's technology platform teams develop new technology and tools for biomedical research, and for clinical and public health applications.
The Biohub allocates one third of its funding towards its extramural programs. The Investigator Program provides five years of funding to scientists from a variety of disciplines who are faculty members at Stanford University, UC Berkeley, and UCSF. As a requirement of the program, investigators meet up twice a month to share findings. The meetings are intended to encourage collaboration and accelerate development of scientific and medical advancements through finding commonalities investigators might not otherwise have known about. The investigator grants are unrestricted, and focused on supporting research that may not be sufficiently developed to qualify for funding from the pharmaceutical industry or the National Institutes of Health.
To increase access to scientific research and promote open science, CZ Biohub requires its Investigators and staff scientists to post submitted manuscripts and related data on preprint servers such as bioRxiv at the same time they are submitted to journals for publication.
Structure and funding
CZ Biohub is structured as a nonprofit, tax-exempt organization, but it has retained close control of the outcomes of its efforts, including patent rights. The Biohub operates independently from CZI but partners with it on some initiatives and programs. In 2016, CZI formed the Biohub with a $600 million endowment over 10 years. In December 2021, CZI announced it was committing up to $1 billion in further funding to support the Biohub's operations through 2031.
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