Talk:Tumor necrosis factor superfamily

	This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Molecular BiologyWikipedia:WikiProject Molecular BiologyTemplate:WikiProject Molecular BiologyMolecular Biology articles
???	This article has not yet received a rating on the importance scale.
	This article is supported by the Molecular and Cell Biology task force (assessed as Mid-importance).

Medicine: Toxicology Low‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Low	This article has been rated as Low-importance on the project's importance scale.
	This article is supported by the Toxicology task force (assessed as Low-importance).

Untitled[edit]

This article is quite poor and adds very little to the article on Tumor necrosis factor-alpha. I strongly suggest that this is merged into that article.JustAnotherKinase (talk) 15:21, 4 July 2010 (UTC)[reply]

"There are more TNF in animals than in human"- What animals? Is there a citation? In biology, "animals" includes humans. —Preceding unsigned comment added by 208.83.126.103 (talk) 15:25, 23 October 2008 (UTC)[reply]

History[edit]

Comment about an old review from '91 seem unhelpful. Many review articles on anti-TNF therapy have been written (very important in a number of auto-immune diseases). There is much important information that could be added to this section. JustAnotherKinase (talk) 15:07, 4 July 2010 (UTC)[reply]

Mechanism[edit]

Should be updated/expanded. Two TNF receptors have been identifiedJustAnotherKinase (talk) 15:07, 4 July 2010 (UTC)[reply]

Emphasize multiplicity of family members[edit]

I just changed section name to "Family members" from "Categories". We should next merge section "Examples" into "Members". This will further reduce motivation to merge this page into main TNF page. Should probably rename this page from "...Factors" to "...Family" because modern literature emphasizes that and uses that nomenclature.C4dn (talk) 08:23, 26 July 2011 (UTC)[reply]

Emphasize commonality of membrane-bound signaling[edit]

We should change "cytokine" (which implies secretion) to "signaling molecule" which better includes ligands displayed on the plasma membrane. Reverse signaling is becoming important in the literature; "cytokines" are not described as capable of reverse signaling. Several journal articles discuss the fact that some members have been successfully identified as reverse signaling due to homologies with other family members sharing motifs on the cytosol side of the cell membrane.C4dn (talk) 08:23, 26 July 2011 (UTC)[reply]