Talk:Endothelial progenitor cell

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Merger proposal[edit]

I propose endothelial stem cell be merged into endothelial progenitor cell.

Endothelial stem cell is a term that has been used infrequently in literature (strict PubMed search returns <20 results), and in most cases refers to cells that would be better characterized as progenitor cells.

http://www.ncbi.nlm.nih.gov/pubmed/?term=%22endothelial+stem+cell%22

On the current ESC page, the majority of citations either talk about developmental cells (angioblasts), highly proliferative EPCs (endothelial colony forming cells or other putative progenitors), or are very far out of date. One citation specifically refers to "stem-like" progenitors, and the other uses the term ESC to refer to the angioblast.

Lucchinetti E, Zeisberger SM, Baruscotti I, Wacker J, Feng J, Dubey R, Zisch AH, Zaugg M. (2009). "Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevofluorane exposure: preconditioning of angiogenic cells by volatile anesthetics". Anesthesia Analgesia 109 (4): 1117–26. doi:10.1213/ane.0b013e3181b5a277.
Kubo H, Alitalo K. (2003). "The bloody fate of endothelial stem cells". Genes and Developmental 17: 322–329. doi:10.1101/gad.1071203

Stem cells are not only defined by their proliferative ability, but by potency; the ability to differentiate into multiple cell types. ESCs as defined on the current wikipedia page do not fit this model.

The text on the page in future efforts already uses the term EPCs, and some sections (sources, role in development of the vascular system, role in cancer) don't mention the ESC at all. I don't believe the ESC is a well enough established or proven concept to have its own page, and believe the information would be better added to endothelial progenitor cell, with some perhaps also moved to hemangioblast or angioblast.

Even the most recent papers regarding so called vascular ESCs refer to them as a subset of highly proliferative ECFCs, which are better classified as progenitors due to unipotency.

http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1001407

Thanks for reading. — Preceding unsigned comment added by DavidOSX (talk • contribs) 17:49, 12 May 2015 (UTC)[reply]

I did a pubmed search for "endothelial stem" and got >60 results! I am not sure that just because ESCs need to be better elucidated that they should be merged with EPCs. They are distinctly different and one comes before the other. 5reh5 (talk) 04:18, 25 September 2015 (UTC) http://www.ncbi.nlm.nih.gov/pubmed?term=endothelial%20stem%5BTitle%2FAbstract%5D[reply]

Closing, given the lack of support over more than 2 year, and the presenence of opposition. Will link with a hatnote to maintain the link between the pages. Klbrain (talk) 21:44, 16 October 2017 (UTC)[reply]

Untitled[edit]

I'm going to update this page significantly in the coming months, starting late Nov/early Dec 2007. Please see the Feb 2007 article in the journal Blood by Yoder and colleagues, and the review in Leukemia by Prater. "EPC" now signifies a very generic term, and is probably not specific enough to cover the many purported EPCs that exist in the literature.

initial announcement[edit]

I'm going to update this page significantly in the coming months, starting late Nov/early Dec 2007. Please see the Feb 2007 article in the journal Blood by Yoder and colleagues, and the review in Leukemia by Prater. "EPC" now signifies a very generic term, and is probably not specific enough to cover the many purported EPCs that exist in the literature.Danprater (talk) 19:59, 21 November 2007 (UTC)[reply]

thought i'd point out that the mention of the Harvard professor John Mayer links to the musician of the same name. 129.2.60.178 (talk) 19:25, 12 December 2007 (UTC)[reply]

I am a graduate student.Now,i am reasearch EPCs.So,i would like to make friends with other researcher.who has the same thinking please contract with me at glmfe1@yahoo.com

Surface coating biomaterials with EPCs[edit]

I'm writing a report on the application of EPCs for biomedical applications. For background, lining synthetic materials (stents, VADs, tissue engineering scaffolds) with EPCs may induce formation of an endothelial layer that protects against thrombosis or restenosis. Here are two reviews if anyone's interested.

1. Avci-Adali M, Paul A, Ziemer G, Wendel HP. New strategies for in vivo tissue engineering by mimicry of homing factors for self-endothelialisation of blood contacting materials. Biomaterials. 2008;29(29):3936-45. Available at: http://www.ncbi.nlm.nih.gov/pubmed/18640715.

2. Avci-Adali M, Ziemer G, Wendel HP. Induction of EPC homing on biofunctionalized vascular grafts for rapid in vivo self-endothelialization--a review of current strategies. Biotechnology advances. 2010;28(1):119-29. Available at: http://www.ncbi.nlm.nih.gov/pubmed/19879347. —Preceding unsigned comment added by Ahaque89 (talk • contribs) 15:56, 3 April 2010 (UTC)[reply]

mechanism[edit]

Recently saw a paper about EPC, so show the part of article for all. SDF-1α plays an important role in the regulation of a variety of cellular functions of EPCs such as cell migration, proliferation, and survival.Despite the apparently important role of CXCR4/SDF-1α in EPC migration, proliferation, survival,and angiogenesis, relatively little is known about the signal transduction pathways that mediate these effects in EPCs. Studies in many cell types have implicated both PI3K/Akt and MAPK/ERK signal transduction pathways in the control of directional cell migration and the sensing of chemoattractant gradients by the cell

Reference-Hao Zheng, PhD, Guosheng Fu, PhD, Tao Dai, PhD, and He Huang, MD. Migration of Endothelial Progenitor Cells Mediated by Stromal Cell–Derived Factor-1a/CXCR4 via PI3K/Akt/eNOS Signal Transduction Pathway. Journal of Cardiovascular Pharmacology 2007:50:274-280 Available at: http://www.ncbi.nlm.nih.gov/pubmed/17878755

Papers questioning their existence[edit]

Before any reinsertion, I think the following text needs attention to its issue of being contradictory to later papers that seem to justify the idea of this cell type very well. At least it should mention on what grounds the concept would be questionable:

Recent discoveries in both mice^[1] and humans^[2] have led scientists and researchers to question the existence of endothelial progenitor cells.

Mikael Häggström (talk) 15:15, 19 August 2011 (UTC)[reply]

References

^ Purhonen S; et al. (2008). "Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth". Proc Natl Acad Sci U S A. 105 (18): 6620–5. doi:10.1073/pnas.0710516105. PMC 2365563. PMID 18443294. {{cite journal}}: Explicit use of et al. in: |author= (help)
^ Yoder MC; et al. (2007). "Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals". Blood. 105(9) (5): 1801–9. doi:10.1182/blood-2006-08-043471. PMC 1801067. PMID 17053059. {{cite journal}}: Explicit use of et al. in: |author= (help)

[1] Purhonen S; et al. (2008). "Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth". Proc Natl Acad Sci U S A. 105 (18): 6620–5. doi:10.1073/pnas.0710516105. PMC 2365563. PMID 18443294. {{cite journal}}: Explicit use of et al. in: |author= (help)

[2] Yoder MC; et al. (2007). "Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals". Blood. 105(9) (5): 1801–9. doi:10.1182/blood-2006-08-043471. PMC 1801067. PMID 17053059. {{cite journal}}: Explicit use of et al. in: |author= (help)

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