Synodical College was a four-year college in Fulton, Missouri, providing education for young women from 1873 until 1928. The school operated under the auspices of the Presbyterian Church. The Synod, meeting in 1871 at Cape Girardeau, Missouri, accepted an offer that year of $16,500 in cash subscriptions from the citizens of Callaway County and 4 acres (16,000 m2) of land, donated by Daniel M. Tucker. The college opened in 1873.
Synodical, also known as Fulton Female Synodical College, was a successor institution to the Fulton Female Academy, which had been opened by Rev. William W. Robertson in 1842 as one of the earliest American women's colleges. It became affiliated with the Presbyterian Church in 1871.
The first board of trustees included: William King, Edwin Curd, W.W. Robertson, C.C. Hersman, John F. Cowan, W.W. Trimble, T.B. Nisbet, Samuel T. Shaw, and Samuel I. McKamey.
The trustees during the final 1927–28 academic year included: C.F. Richmond, John E. Kerr, T.P. Harrison, C.R. Nisbet, S.G. Wood, T.R.R. Ely, C.A. McPheeters, J.W. Gallaher, J.W. McKamey, E.J. Grant, J.G. McConkey, I Cochran Hunt, R.S. Boyd, and Joseph Rennie.
T.O. Rogers, 1873–1874; W.W. Hill, 1874–1877; B.H. Charles, 1877–1888; H.C. Evans, 1888–1893; John W. Primrose, 1893–1896; Thomas Peyton Walton (previously president of Elizabeth Aull Seminary at Lexington, Missouri) followed; John James, 1914-1924; and Colin A. McPheeters served as Acting President during the final 1927–28 academic year.
Synodical College was recognized by the University of Missouri as a standard junior college after 1916. In 1925 the Synod of Missouri approved a resolution, at a meeting in St. Joseph, Missouri, to enhance the curriculum with the goal of providing a four-year collegiate program. The initial steps toward the goal included an affiliation agreement with Westminster College to share some faculty and courses. Synodical College closed in 1928.
- Hallie Paxson Winsborough (1865–1940), American church worker
- Conrad, ed. Encyclopedia of the History of Missouri, vol. VI. 1901. pp. 147–8.
- Parrish, William E. Westminster College: An Informal History, 1851-1999. 2000. pp. 51, 165.
- Synodical College Catalog, 1927-28, vol. XIII. June, 1927.
- Williams, Walter. The State of Missouri. 1901. p. 342.
- List of current and historical women's universities and colleges
- Timeline of women's colleges in the United States