Gil McVean

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Gil McVean

FRS FMedSci
McVean in 2016
Born
Gilean Alistair Tristram McVean

February 1973 (age 51)
NationalityBritish
Alma mater
Awards
Scientific career
Institutions
ThesisAdaptation and conflict : the differences between the sexes in mammalian genome evolution (1998)
Doctoral advisorLaurence Hurst[2][3][4]
Other academic advisors
WebsiteProfessor Gil McVean - University of Oxford

Gilean Alistair Tristram McVean FRS FMedSci[5] (born February 1973)[6] is a professor of statistical genetics at the University of Oxford,[7] fellow of Linacre College, Oxford and co-founder and director of Genomics plc.[6][8] He also co-chaired the 1000 Genomes Project analysis group.[9][10]

Education[edit]

Gilean McVean speaking at the 2010 GEM meeting at the Wellcome Trust Sanger Institute, Hinxton

From 1991-94, he completed a Bachelor of Arts degree in Biological Sciences at the University of Oxford.[11] He completed his PhD in the Department of Genetics at the University of Cambridge supervised by Laurence Hurst[12][13] in 1998.[3][14]

Career and research[edit]

McVean completed postdoctoral research at the University of Edinburgh from 1997 to 2000, supervised by Brian and Deborah Charlesworth.[15][14]

From 2000-04, he was a Royal Society University Research Fellow in the Department of Statistics at Oxford, where he has also been a University lecturer in Mathematical Genetics since 2004. He was reappointed in 2009 until retirement age.[16] In October 2006, he was appointed professor of statistical genetics at the University of Oxford.[17]

McVean's research[18] focuses on population genetics, statistics[19] and evolutionary biology including the International HapMap Project,[20][21] recombination rates in the human genome[22] and the 1000 Genomes Project.[23][24]

McVean developed a statistical method to look at recombination rate which helped to identify PRDM9 as a hotspot positioning gene.[25] In 2014, with Peter Donnelly, McVean co-founded Genomics plc, a genomics analysis company, as a corporate spin-off of the University of Oxford.[6] In 2017, he was a founding director of the Big Data Institute at the University of Oxford.[26]

Honours and awards[edit]

In 2006 McVean was awarded a Philip Leverhulme Prize.[27][28]

In 2010, McVean was awarded the Francis Crick Medal and delivered that year's lecture entitled "Our genomes, our history".[29]

In 2012, he was awarded the Weldon Memorial Prize.[30]

In 2013, he presented a talk TEDxWarwick entitled A Thousand Genomes a Thousand Stories.[31]

In May 2014, McVean was elected as a member of the European Molecular Biology Organisation.[32]

McVean was elected Fellow of the Royal Society (FRS) in 2016[5] and a Fellow of the Academy of Medical Sciences (FMedSci).[33][34]

References[edit]

  1. ^ "Francis Crick Medal and Lecture 2010 - Our genomes, our history". Royal Society. Retrieved 27 January 2022.
  2. ^ Hurst, L.; McVean, G. (1996). "A difficult phase for introns-early. Molecular evolution". Current Biology. 6 (5): 533–36. doi:10.1016/S0960-9822(02)00535-3. PMID 8805261.
  3. ^ a b McVean, Gilean Alistair Tristram (1998). Adaptation and conflict: the differences between the sexes in mammalian genome evolution (PhD thesis). University of Cambridge. OCLC 894602716.
  4. ^ "Students and post-docs past and present in the Hurst laboratory". University of Bath. Archived from the original on 15 May 2015.
  5. ^ a b Anon (2016). "Gilean McVean". royalsociety.org. London: Royal Society. Archived from the original on 29 April 2016.
  6. ^ a b c Anon (2016). "Gilean MCVEAN Profile". companieshouse.gov.uk. London: Companies House. Archived from the original on 12 August 2016.
  7. ^ McVean Group at the University of Oxford
  8. ^ "Prof. Gil McVean - GENOMICS plc". Retrieved 30 December 2017.
  9. ^ "Oct 10: 1000 Genomes project - Wellcome Trust Centre for Human Genetics". www.well.ox.ac.uk. Archived from the original on 10 September 2018. Retrieved 30 December 2017.
  10. ^ Gil McVean publications from Europe PubMed Central
  11. ^ Gil McVean's ORCID 0000-0002-5012-4162
  12. ^ McVean, G.T.; Hurst, L.D. (1997). "Evidence for a selectively favourable reduction in the mutation rate of the X chromosome". Nature. 386 (6623): 388–92. Bibcode:1997Natur.386..388M. doi:10.1038/386388a0. PMID 9121553. S2CID 4343123.
  13. ^ Hurst, L.D.; McVean, G.T. (1996). "...And scandalous symbionts". Nature. 381 (6584): 650–51. Bibcode:1996Natur.381..650H. doi:10.1038/381650a0. PMID 8649507.
  14. ^ a b "Gilean McVean profile". Oxford University. Archived from the original on 24 October 2017. Retrieved 30 December 2017.
  15. ^ Charlesworth, D.; Charlesworth, B.; McVean, G. (2001). "Genome sequences and evolutionary biology, a two-way interaction". Trends in Ecology & Evolution. 16 (5): 235–42. doi:10.1016/S0169-5347(01)02126-7. PMID 11301152.
  16. ^ "Oxford University Gazette - Reappointments". ox.ac.uk. 14 May 2009. Archived from the original on 30 May 2009. Retrieved 30 December 2017.
  17. ^ "Oxford University Gazette". ox.ac.uk. Archived from the original on 2 October 2013. Retrieved 12 July 2016.
  18. ^ Gilean McVean profile, Google Scholar; accessed 30 December 2017.
  19. ^ Reshef, D. N.; Reshef, Y. A.; Finucane, H. K.; Grossman, S. R.; McVean, G.; Turnbaugh, P. J.; Lander, E. S.; Mitzenmacher, M.; Sabeti, P. C. (2011). "Detecting Novel Associations in Large Data Sets". Science. 334 (6062): 1518–1524. Bibcode:2011Sci...334.1518R. doi:10.1126/science.1205438. PMC 3325791. PMID 22174245.
  20. ^ Frazer, K. A.; Frazer, D. G.; Ballinger, D. R.; Cox, D. A.; Hinds, L. L.; Stuve, R. A.; Gibbs, J. W.; Belmont, A.; Boudreau, P.; Hardenbol, S. M.; Leal, S.; Pasternak, D. A.; Wheeler, T. D.; Willis, F.; Yu, H.; Yang, C.; Zeng, Y.; Gao, H.; Hu, W.; Hu, C.; Li, W.; Lin, S.; Liu, H.; Pan, X.; Tang, J.; Wang, W.; Wang, J.; Yu, B.; Zhang, Q.; et al. (2007). "A second generation human haplotype map of over 3.1 million SNPs". Nature. 449 (7164): 851–61. Bibcode:2007Natur.449..851F. doi:10.1038/nature06258. PMC 2689609. PMID 17943122.
  21. ^ Sabeti, Pardis C.; Varilly, Patrick; Fry, Ben; Lohmueller, Jason; Hostetter, Elizabeth; Cotsapas, Chris; Xie, Xiaohui; Byrne, Elizabeth H.; McCarroll, Steven A.; Gaudet, Rachelle; Schaffner, Stephen F.; Lander, Eric S.; The International HapMap Consortium; Frazer, Kelly A.; Ballinger, Dennis G.; Cox, David R.; Hinds, David A.; Stuve, Laura L.; Gibbs, Richard A.; Belmont, John W.; Boudreau, Andrew; Hardenbol, Paul; Leal, Suzanne M.; Pasternak, Shiran; Wheeler, David A.; Willis, Thomas D.; Yu, Fuli; Yang, Huanming; Zeng, Changqing Zeng; et al. (2007). "Genome-wide detection and characterization of positive selection in human populations". Nature. 449 (7164): 913–918. Bibcode:2007Natur.449..913S. doi:10.1038/nature06250. PMC 2687721. PMID 17943131.
  22. ^ McVean, G. A. T.; Myers, S.; Hunt, S.; Deloukas, P.; Bentley, D.; Donnelly, P. (2004). "The Fine-Scale Structure of Recombination Rate Variation in the Human Genome". Science. 304 (5670): 581–584. Bibcode:2004Sci...304..581M. doi:10.1126/science.1092500. PMID 15105499. S2CID 20616898.
  23. ^ Danecek, P.; Auton, A.; Abecasis, G.; Albers, C. A.; Banks, E.; Depristo, M. A.; Handsaker, R.; Lunter, G.; Marth, G.; Sherry, S. T.; McVean, G.; Durbin, R.; 1000 Genomes Project Analysis Group (2011). "The Variant Call Format and VCFtools". Bioinformatics. 27 (15): 2156–58. doi:10.1093/bioinformatics/btr330. PMC 3137218. PMID 21653522.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  24. ^ Hernandez, R. D.; Kelley, J. L.; Elyashiv, E.; Melton, S. C.; Auton, A.; McVean, G.; 1000 Genomes Project; Sella, G.; Przeworski, M. (2011). "Classic Selective Sweeps Were Rare in Recent Human Evolution". Science. 331 (6019): 920–24. Bibcode:2011Sci...331..920H. doi:10.1126/science.1198878. PMC 3669691. PMID 21330547.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  25. ^ "Gilean McVean". royalsociety.org. Retrieved 30 December 2017.
  26. ^ "Professor Cecilia Lindgren appointed Director of the Big Data Institute — Oxford Big Data Institute". www.bdi.ox.ac.uk. Retrieved 29 April 2021.
  27. ^ "AWARDS MADE IN 2006" (PDF). leverhulme.ac.uk. The Leverhulme Trust. 2006. Archived from the original (PDF) on 10 August 2016. Retrieved 30 December 2017.
  28. ^ "Philip Leverhulme Prizes 2006" (PDF). leverhulme.ac.uk. The Leverhulme Trust. 2006. Retrieved 30 December 2017.
  29. ^ The Royal Society (10 December 2013), Our genomes, our history, archived from the original on 15 December 2021, retrieved 30 December 2017
  30. ^ "Professor Gil McVean awarded the Weldon Memorial Prize 2012 - Wellcome Trust Centre for Human Genetics". well.ox.ac.uk. Retrieved 30 December 2017.
  31. ^ TEDx Talks (29 March 2013), A Thousand Genomes a Thousand Stories: Gilean McVean at TEDxWarwick 2013, archived from the original on 15 December 2021, retrieved 30 December 2017
  32. ^ "EMBO enlarges its membership for 50th anniversary". embo.org. Retrieved 30 December 2017.
  33. ^ "New Fellows: Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 30 December 2017.
  34. ^ "Professor Gil McVean elected a Fellow of the Royal Society - GENOMICS plc". Retrieved 30 December 2017.
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