He was born on 2 March 1868 in Villnachern to Edmund Schulthess (1826–1906) and Cornelia Brigitta Marth (1828–1896).
He was elected to the Swiss Federal Council on 17 July 1912 and handed over office on 15 April 1935. He was affiliated to the Free Democratic Party. During his time in office he held the following departments:
- Department of Trade, Industry and Agriculture (1912–1914)
- Department of Economic Affairs (1915–1935)
He was President of the Confederation four times in 1917, 1921, 1928 and 1933.
He died on 22 April 1944 in Bern.
He married Marguerite Jeanne Disqué (born c. 1880) and had a daughter Nelly Marguerite Jeanne Schulthess, born in Switzerland on 13 August 1903. Like her parents, she married at the Church of the Holy Trinity in Bern on 30 November 1933. She and her Portuguese husband (Vasco Francisco Caetano de Castro Coutinho de Quevedo Pessanha, born in Lisbon, Coração de Jesus, on 3 July 1909) continued the family line.
- Edmund Schulthess in German, French and Italian in the online Historical Dictionary of Switzerland.
- Profile of Edmund Schulthess with election results on the website of the Swiss Federal Council.
- Edmund Schulhess in History of Social Security in Switzerland
- Newspaper clippings about Edmund Schulthess in the 20th Century Press Archives of the ZBW