ABI gene family member 3

ABI3
Identifiers
Aliases	ABI3, NESH, SSH3BP3, ABI family member 3
External IDs	OMIM: 606363 MGI: 1913860 HomoloGene: 9505 GeneCards: ABI3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	49,223,225 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	95,733,302 bp
RNA expression pattern
	Top expressed in
	spleen; ; monocyte; ; blood; ; appendix; ; parotid gland; ; lymph node; ; upper lobe of left lung; ; right lung; ; right lobe of thyroid gland; ; left ventricle;
	Top expressed in
	thymus; ; interventricular septum; ; spleen; ; blood; ; right lung; ; jejunum; ; subcutaneous adipose tissue; ; yolk sac; ; right lung lobe; ; pharynx;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; SH3 domain binding;
Cellular component	cytoplasm; intracellular anatomical structure; membrane; lamellipodium;
Biological process	peptidyl-tyrosine phosphorylation; regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	51225
	66610
	ENSG00000108798
	ENSMUSG00000018381
	Q9P2A4
	Q8BYZ1
	NM_001135186; NM_016428
	NM_001163464; NM_025659
	NP_001128658; NP_057512
	NP_001156936; NP_079935
	Wikidata
View/Edit Human	View/Edit Mouse

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.^[5]^[6]^[7]

Function[edit]

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.^[7]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108798 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018381 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
^ Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
^ ^a ^b "Entrez Gene: ABI3 ABI gene family, member 3".

External links[edit]

Human ABI3 genome location and ABI3 gene details page in the UCSC Genome Browser.

Further reading[edit]

Ichigotani Y, Fujii K, Hamaguchi M, Matsuda S (2002). "In search of a function for the E3B1/Abi2/Argbp1/NESH family (Review)". Int. J. Mol. Med. 9 (6): 591–5. doi:10.3892/ijmm.9.6.591. PMID 12011975.
Miyazaki K, Matsuda S, Ichigotani Y, et al. (2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim. Biophys. Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Matsuda S, Iriyama C, Yokozaki S, et al. (2001). "Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3". J. Hum. Genet. 46 (8): 483–6. doi:10.1007/s100380170049. PMID 11501947.
Ichigotani Y, Yokozaki S, Fukuda Y, et al. (2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Hirao N, Sato S, Gotoh T, et al. (2007). "NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation". FEBS Lett. 580 (27): 6464–70. doi:10.1016/j.febslet.2006.10.065. PMID 17101133. S2CID 20005197.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108798 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018381 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10978530-5] Miyazaki K, Matsuda S, Ichigotani Y, Takenouchi Y, Hayashi K, Fukuda Y, Nimura Y, Hamaguchi M (Nov 2000). "Isolation and characterization of a novel human gene (NESH) which encodes a putative signaling molecule similar to e3B1 protein". Biochim Biophys Acta. 1493 (1–2): 237–41. doi:10.1016/s0167-4781(00)00158-5. PMID 10978530.

[pmid11956071-6] Ichigotani Y, Yokozaki S, Fukuda Y, Hamaguchi M, Matsuda S (Apr 2002). "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells". Cancer Res. 62 (8): 2215–9. PMID 11956071.

[entrez-7] "Entrez Gene: ABI3 ABI gene family, member 3".

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